Performing a literature review
Citations Over TimeTop 21% of 2012 papers
Abstract
Poloxamer (Pluronic®) nonionic surfactant vehicles are a series of chemically-related block copolymers finding widespread use in parenteral formulations as solubilizing and wetting agents for traditional, low-molecular weight organic drug molecules, as well as stabilizing agents for proteins and polypeptide drugs. We report the effects of poloxamer 407 (Pluronic® F-127) on plasma cholesterol and triglyceride concentrations in rats. Poloxamer 407 injected into rats by intraperitoneal injection (dose = 1.5 gm/kg) resulted in sustained (greater than 96 hour) hypercholesterolemia and hypertriglyceridemia. A larger dose of poloxamer 407 was required to elevate plasma triglyceride relative to total cholesterol. Ingestion of commercial rat chow had a negligible effect on plasma cholesterol and triglycerides levels in control (no poloxamer injection) animals, but consumption of food by animals that received an intraperitoneal injection of poloxamer 407 (30% w/w) resulted in significantly (p
Related Papers
- → Intratumoral Administration of Paclitaxel in an In Situ Gelling Poloxamer 407 Formulation(2002)83 cited
- → Use of factorial design in formulation and evaluation of intrarectal in situ gel of sumatriptan(2023)15 cited
- → Effects of poloxamer 407 on the assembly, structure and dissolution of fibrin clots(1996)7 cited
- Study on Formulation of Breviscapine in Situ Nasal Thermoreversible Gel(2013)
- Phase Transition of Poloxamer 407 : Poloxamer 407의 상전이(2000)