A high-field proton magnetic resonance and nuclear Overhauser effect study of prostaglandin E2
Canadian Journal of Chemistry1980Vol. 58(15), pp. 1577–1583
Abstract
The proton magnetic resonance ( 1 H nmr) spectrum of prostaglandin E 2 (PGE 2 ) in CDCl 3 at 400 MHz bas been completely analyzed utilizing homonuclear double resonance, inversion recovery, and nOe difference experiments. The nOe difference experiments are used to assign points of configuration, namely the H-10β and the H-10α proton resonances. A spectral analysis shows that the two protons at C-3 and the two protons at C-4 are nonequivalent, indicating a hindered rotation of the chain. This is possibly due to the hairpin conformation of PGE 2 in solution.
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