Identification of domoic acid, a neuroexcitatory amino acid, in toxic mussels from eastern Prince Edward Island
Canadian Journal of Chemistry1989Vol. 67(3), pp. 481–490
Citations Over TimeTop 1% of 1989 papers
Jeffrey L. C. Wright, R. K. Boyd, Arlan Silva Freitas, Michael Falk, R. A. Foxall, W. D. Jamieson, M. V. Laycock, A. W. McCulloch, A. G. McInnes, P. H. Odense, Vibha Pathak, Michael A. Quilliam, Mark A. Ragan, P. G. Sim, Pierre Thibault, John A. Walter, Michael W. Gilgan, D J A Richard, Danielle Dewar
Abstract
The causative agent of toxicity in cultured mussels from a localized area of eastern Prince Edward Island has been identified as domoic acid, a neuroexcitatory amino acid. The toxin was isolated by a number of different bioassay-directed separation techniques including high-performance liquid chromatography, high-voltage paper electrophoresis, and ion-exchange chromatography, and characterized by a number of spectroscopic techniques including ultraviolet, infrared, mass spectrometry, and nuclear magnetic resonance. The isolation and purification methods are described in detail and some new analytical data for domoic acid are reported. Keywords: shellfish toxin, domoic acid, neurotoxin, bioassay-directed analysis.
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