Time Course and Magnitude of Movement-Related Gating of Tactile Detection in Humans. I. Importance of Stimulus Location

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Abstract

Williams, Stephan R., Jafar Shenasa, and C. Elaine Chapman. Time course and magnitude of movement-related gating of tactile detection in humans. I. Importance of stimulus location. J. Neurophysiol. 79: 947–963, 1998. The time course and spatial extent of movement-related suppression of the detection of weak electrical stimuli (intensity, 90% detected at rest) was determined in 118 experiments carried out in 47 human subjects. Subjects were trained to perform a rapid abduction of the right index finger (D2) in response to a visual cue. Stimulus timing was calculated relative to the onset of movement and the onset of electromyographic (EMG) activity. Electrical stimulation was delivered to 10 different sites on the body, including sites on the limb performing the movement (D2, D5, hand, forearm and arm) as well as several distant sites (contralateral arm, ipsilateral leg). Detection of stimuli applied to the moving digit diminished significantly and in a time-dependent manner, with the first significant decrease occurring 120 ms before movement onset and 70 ms before the onset of EMG activity. Movement-related and time-dependent effects were obtained at all stimulation sites on the homolateral arm as well as the adjacent trunk. A pronounced spatiotemporal gradient was observed: the magnitude of the movement-related decrease in detectability was greatest and earliest at sites closest to the moving finger and progressively weaker and later at more proximal sites. When stimuli were applied to the distant sites, only a small (∼10%), non-time–dependent decrease was observed during movement trials. A simple model of perceptual performance adequately described the results, providing insight into the distribution of movement-related inhibitory controls within the CNS.

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