Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease
Citations Over TimeTop 10% of 2018 papers
Abstract
Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and fluid to and from the luminal contents. At the same time, epithelial cells are responsible for forming a physical and biochemical barrier that prevents the entry into the body of harmful agents, such as bacteria and their toxins. Dysregulation of epithelial transport and barrier function is associated with the pathogenesis of a number of conditions throughout the intestine, such as inflammatory bowel disease, chronic diarrhea, pancreatitis, reflux esophagitis, and cancer. Driven by discovery of specific receptors on intestinal epithelial cells, new insights into mechanisms that control their synthesis and enterohepatic circulation, and a growing appreciation of their roles as bioactive bacterial metabolites, bile acids are currently receiving a great deal of interest as critical regulators of epithelial function in health and disease. This review aims to summarize recent advances in this field and to highlight how bile acids are now emerging as exciting new targets for disease intervention.
Related Papers
- → Bile acids as metabolic regulators(2015)273 cited
- → Metabolic effects of intestinal absorption and enterohepatic cycling of bile acids(2015)118 cited
- → Dynamics of the enterohepatic circulation of bile acids in healthy humans(2021)59 cited
- → Influence of age on intestinal bile acid transport in C57BL/6 mice(2017)11 cited
- [Hypolipidemic drugs--ileal Na+/bile acid cotransporter inhibitors (S-8921 etc)].(2002)