Angiopoietin-2 Levels Are Associated with Disease Progression in Metastatic Malignant Melanoma
Clinical Cancer Research2009Vol. 15(4), pp. 1384–1392
Citations Over TimeTop 10% of 2009 papers
Iris Helfrich, Lutz Edler, Antje Sucker, Markus Thomas, Sven Christian, Dirk Schadendorf, Hellmut G. Augustin
Abstract
The experiments establish sAng-2 as a biomarker of melanoma progression and metastasis correlating with tumor load and overall survival. The identification of an autocrine angiopoietin/Tie loop controlling melanoma migration and invasion warrants further functional experiments and validate the angiopoietin/Tie system as a promising therapeutic target for human melanomas.
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