Replication of Genetic Polymorphisms Reported to Be Associated with Taxane-Related Sensory Neuropathy in Patients with Early Breast Cancer Treated with Paclitaxel
Clinical Cancer Research2014Vol. 20(9), pp. 2466–2475
Citations Over TimeTop 10% of 2014 papers
Jean Abraham, Qi Guo, Leila Dorling, Jonathan P. Tyrer, Susan Ingle, Richard Hardy, Anne-Laure Vallier, Louise Hiller, Stephen R. Russell, Linda Jones, S. Bowden, Janet Dunn, Christopher Poole, Carlos Caldas, Paul D.P. Pharoah, Helena Earl
Abstract
This is currently the largest study investigating SNPs associated with TRSN. We found strong evidence that SNPs within genes in taxane pharmacokinetic and pharmacodynamic pathways contribute to TRSN risk. However, a large proportion of the inter-individual variability in TRSN remains unexplained. Further validated results from GWAS will help to identify new pathways, genes, and SNPs involved in TRSN susceptibility.
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