Comparison of Biomarker Assays for EGFR : Implications for Precision Medicine in Patients with Glioblastoma
Clinical Cancer Research2019Vol. 25(11), pp. 3259–3265
Citations Over TimeTop 10% of 2019 papers
Andrew B. Lassman, Lisa Roberts-Rapp, И. А. Соколова, Minghao Song, Ekaterina Pestova, Rupinder Kular, Carolyn Mullen, Zheng Zha, Xin Lü, Erica Gomez, Anahita Bhathena, David Maag, Priya Kumthekar, Hui Gan, Andrew M. Scott, М Р Гусева, Kyle D. Holen, Peter Ansell, Martin J. van den Bent
Abstract
Methods for assessing EGFR mRNA expression (RT-PCR, RNAseq) and copy number (WES), but not protein expression (IHC), can be used as surrogates for EGFR amplification (FISH) in GBM. Collectively, our results provide enhanced understanding of available screening options for patients, which may help guide EGFR-targeted therapeutic approaches.
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