Potential Action of IL-4 and IL-13 as Fibrogenic Factors on Lung Fibroblasts in vitro
International Archives of Allergy and Immunology2003Vol. 132(2), pp. 168–176
Citations Over TimeTop 10% of 2003 papers
Abstract
IL-4 and IL-13 induce differentiation of fibroblasts to myofibroblasts and this response is attenuated by IFN-gamma. IL-4 and IL-13 stimulate fibroblast proliferation and this effect is at least partly due to suppressed COX gene expressions and subsequently decreased PGE(2) production. These findings suggest that IL-4 and IL-13 directly act on lung fibroblast to induce a fibrogenic response.
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