Characteristics of Gintonin-Mediated Membrane Depolarization of Pacemaker Activity in Cultured Interstitial Cells of Cajal
Cellular Physiology and Biochemistry2014Vol. 34(3), pp. 873–890
Citations Over TimeTop 1% of 2014 papers
Byung Joo Kim, Joo‐Hyun Nam, Kyun Ha Kim, Myungsoo Joo, Tal Soo Ha, Kwon-Yeon Weon, Seok Choi, Jae Yeoul Jun, Eun‐Jung Park, Jinhong Wie, Insuk So, Seung-Yeol Nah
Abstract
Gintonin-mediated membrane depolarization of pacemaker activity and ANO1 activation are coupled to the stimulation of GI contractility through LPA1/3 receptor signaling pathways in cultured murine ICC. Gintonin might be a ingredient responsible for ginseng-mediated GI tract modulations, and could be a novel candidate for development as a prokinetic agent that may prevent or alleviate GI motility dysfunctions in human patients.
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