Is Intra-Arterial Treatment for Acute Ischemic Stroke Less Effective in Women than in Men
Interventional Neurology2016Vol. 5(3-4), pp. 174–178
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Inger R. de Ridder, Puck Fransen, Debbie Beumer, Olvert A. Berkhemer, Lucie A. van den Berg, Marieke J.H. Wermer, Hester Lingsma, Wim H. van Zwam, Yvo B.W.E.M. Roos, Robert J. van Oostenbrugge, Charles B.L.M. Majoie, Aad van der Lugt, Diederik W.J. Dippel, for the MR CLEAN Investigators
Abstract
Contrary to other studies, we found a significant interaction between sex and treatment effect in the MR CLEAN trial. Pooled analyses of all published thrombectomy trials did not confirm this finding. In MR CLEAN, women seem to have a slightly more unfavorable profile, causing higher mortality and more serious adverse events, but insufficient to explain the absence of an overall effect. This suggests a play of chance and makes it clear that IAT should not be withheld in women.
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