T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans
Arteriosclerosis Thrombosis and Vascular Biology2014Vol. 34(12), pp. 2637–2643
Citations Over TimeTop 1% of 2014 papers
Tracey McLaughlin, Lifen Liu, Cindy Lamendola, Lei Shen, John M. Morton, Homero Rivas, Daniel A. Winer, Lorna Tolentino, Okmi Choi, Hong Zhang, Melissa Hui Yen Chng, Edgar G. Engleman
Abstract
CD4 and CD8 T cells populate human adipose tissue and the relative frequency of Th1 and Th2 are highly associated with systemic inflammation and insulin resistance. These findings point to the adaptive immune system as a potential mediator between obesity and insulin resistance or inflammation. Identification of antigenic stimuli in adipose tissue may yield novel targets for treatment of obesity-associated metabolic disease.
Related Papers
- → Proinflammatory Cytokines Mediate GPCR Dysfunction(2017)19 cited
- → MicroRNA-345-3p is a potential biomarker and ameliorates rheumatoid arthritis by reducing the release of proinflammatory cytokines(2023)3 cited
- → Induction of inducible nitric oxide synthase and proinflammatory cytokines expression by o,p′-DDT in macrophages(2004)45 cited
- → Dihydrocapsaicin suppresses proinflammatory cytokines expression by enhancing nuclear factor IA in a NF-κB-dependent manner(2016)20 cited
- Effects of Proinflammatory Cytokines in the Heart(2004)