Endothelial Uncoupling Protein 2 Regulates Mitophagy and Pulmonary Hypertension During Intermittent Hypoxia
Arteriosclerosis Thrombosis and Vascular Biology2015Vol. 35(5), pp. 1166–1178
Citations Over TimeTop 10% of 2015 papers
Maria Haslip, Iva Dostanic, Yan Huang, Yi Zhang, Kerry S. Russell, Michael J. Jurczak, Praveen Mannam, Frank J. Giordano, Serpil C. Erzurum, Patty J. Lee
Abstract
The loss of endothelial Ucp2 leads to excessive PTEN-induced putative kinase 1-induced mitophagy, inadequate mitochondrial biosynthesis, and increased apoptosis in endothelium. An endothelial Ucp2-PTEN-induced putative kinase 1 axis may be effective therapeutic targets in PH.
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