Endothelial PHACTR1 Promotes Endothelial Activation and Atherosclerosis by Repressing PPARγ Activity Under Disturbed Flow in Mice
Arteriosclerosis Thrombosis and Vascular Biology2023Vol. 43(8), pp. e303–e322
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Dongyang Jiang, Hao Liu, Guofu Zhu, Xiankai Li, Linlin Fan, Faxue Zhao, Chong Xu, Shumin Wang, Yara Rose, Jordan Rhen, Ze Yu, Yiheng Yin, Yuling Gu, Xiangbin Xu, Edward A. Fisher, Junbo Ge, Yawei Xu, Jinjiang Pang
Abstract
Our results identified endothelial PHACTR1 as a novel PPARγ corepressor to promote atherosclerosis in disturbed flow regions. Endothelial PHACTR1 is a potential therapeutic target for atherosclerosis treatment.
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