Stimulating Cardiac Muscle by Light
Circulation Arrhythmia and Electrophysiology2011Vol. 4(5), pp. 753–760
Citations Over TimeTop 10% of 2011 papers
Zhiheng Jia, Virginijus Valiūnas, Zongju Lu, Harold Bien, Huilin Liu, Hong‐Zhang Wang, Barbara Rosati, Peter R. Brink, Ira S. Cohen, Emilia Entcheva
Abstract
Our results demonstrate feasibility to control excitation and contraction in cardiac muscle by light, using the TCU approach. Optical pacing in this case uses less energy, offers superior spatiotemporal control and remote access and can serve not only as an elegant tool in arrhythmia research but may form the basis for a new generation of light-driven cardiac pacemakers and muscle actuators. The TCU strategy is extendable to (nonviral) stem cell therapy and is directly relevant to in vivo applications.
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