Regenerative Potential of Cardiosphere-Derived Cells Expanded From Percutaneous Endomyocardial Biopsy Specimens
Circulation2007Vol. 115(7), pp. 896–908
Citations Over TimeTop 1% of 2007 papers
Rachel Smith, Lucio Barile, Hee Cheol Cho, Michelle K. Leppo, Joshua M. Hare, Elisa Messina, Alessandro Giacomello, M. Roselle Abraham, Eduardo Marbán
Abstract
A method is presented for the isolation of adult human stem cells from endomyocardial biopsy specimens. CDCs are cardiogenic in vitro; they promote cardiac regeneration and improve heart function in a mouse infarct model, which provides motivation for further development for therapeutic applications in patients.
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