Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure
Circulation2009Vol. 119(10), pp. 1386–1397
Citations Over TimeTop 10% of 2009 papers
Tariq Hamid, Yan Gu, Roger V. Ortines, C. Bhattacharya, Guangwu Wang, Yu‐Ting Xuan, Sumanth D. Prabhu
Abstract
TNFR1 and TNFR2 have disparate and opposing effects on remodeling, hypertrophy, NF-kappaB, inflammation, and apoptosis in HF: TNFR1 exacerbates, whereas TNFR2 ameliorates, these events. However, signaling through both receptors is required to induce diastolic dysfunction and oxidative stress. TNFR-specific effects in HF should be considered when therapeutic anti-TNF strategies are developed.
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