Dietary Nitrate Ameliorates Pulmonary Hypertension
Circulation2012Vol. 125(23), pp. 2922–2932
Citations Over TimeTop 10% of 2012 papers
Reshma S. Baliga, Alexandra Milsom, Suborno M. Ghosh, Sarah L. Trinder, Raymond J. MacAllister, Amrita Ahluwalia, Adrian J. Hobbs
Abstract
These data demonstrate that dietary nitrate, and to a lesser extent dietary nitrite, elicit pulmonary dilatation, prevent pulmonary vascular remodeling, and reduce the right ventricular hypertrophy characteristic of PH. This favorable pharmacodynamic profile depends on endothelial NO synthase and xanthine oxidoreductase -catalyzed reduction of nitrite to NO. Exploitation of this mechanism (ie, dietary nitrate/nitrite supplementation) represents a viable, orally active therapy for PH.
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