Cannabinoid Receptor 2-Centric Molecular Feedback Loop Drives Necroptosis in Diabetic Heart Injuries
Circulation2022Vol. 147(2), pp. 158–174
Citations Over TimeTop 10% of 2022 papers
Pan Gao, Mengying Cao, Xueli Jiang, Xiaolin Wang, Guoping Zhang, Xinru Tang, Chunjie Yang, Issei Komuro, Junbo Ge, Liliang Li, Yunzeng Zou
Abstract
CB2R transcriptionally repressed necroptosis through interaction with BACH2; in turn, MLKL formed a negative feedback to phosphorylate CB2R. Our study provides the integrative view of a novel molecular mechanism loop for regulation of necroptosis centered by CB2R, which represents a promising alternative strategy for controlling diabetic heart dysfunction.
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