Mkk4 Is a Negative Regulator of the Transforming Growth Factor Beta 1 Signaling Associated With Atrial Remodeling and Arrhythmogenesis With Age
Journal of the American Heart Association2014Vol. 3(2), pp. e000340–e000340
Citations Over TimeTop 10% of 2014 papers
Laura Davies, Jiawei Jin, Weijin Shen, Hoyee Tsui, Ying Shi, Yanwen Wang, Yanmin Zhang, Guoliang Hao, Jingjing Wu, Si Chen, James A. Fraser, Nianguo Dong, Vincent M. Christoffels, Ursula Ravens, Christopher Huang, Henggui Zhang, Elizabeth J. Cartwright, Xin Wang, Ming Lei
Abstract
These findings together demonstrate, for the first time, that Mkk4 is a negative regulator of the TGF-β1 signaling associated with atrial remodeling and arrhythmogenesis with age, establishing Mkk4 as a new potential therapeutic target for treating AF.
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