Edaravone, a Free Radical Scavenger, Inhibits MMP-9–Related Brain Hemorrhage in Rats Treated With Tissue Plasminogen Activator
Stroke2008Vol. 40(2), pp. 626–631
Citations Over TimeTop 10% of 2008 papers
Kenji Yagi, Keiko T. Kitazato, Masaaki Uno, Yoshiteru Tada, T. Kinouchi, Kenji Shimada, Shinji Nagahiro
Abstract
We demonstrate that edaravone inhibits rtPA-induced cerebral hemorrhage in the ischemic brain of rats via the inhibition of MMP-9 expression in vivo, which is substantiated by inhibition of MMP-9 expression and NF-kappaB activation in HBECs. Edaravone may render thrombolytic therapy safer for the administration of rtPA in patients with ischemic stroke.
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