Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia
Stroke2012Vol. 43(11), pp. 3063–3070
Citations Over TimeTop 1% of 2012 papers
Xiaoming Hu, Peiying Li, Yanling Guo, Haiying Wang, Rehana K. Leak, Songela Chen, Yanqin Gao, Jun Chen
Abstract
Our results suggest that microglia/macrophages respond dynamically to ischemic injury, experiencing an early "healthy" M2 phenotype, followed by a transition to a "sick" M1 phenotype. These dual and opposing roles of microglia/macrophages suggest that stroke therapies should be shifted from simply suppressing microglia/macrophage toward adjusting the balance between beneficial and detrimental microglia/macrophage responses.
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