Cerebral Edema in Patients With Large Hemispheric Infarct Undergoing Reperfusion Treatment: A HERMES Meta-Analysis
Stroke2021Vol. 52(11), pp. 3450–3458
Citations Over TimeTop 10% of 2021 papers
Felix Ng, Nawaf Yassi, Gagan Sharma, Scott Brown, Mayank Goyal, Charles B.L.M. Majoie, Tudor G. Jovin, Michael D. Hill, Keith W. Muir, Jeffrey L. Saver, Françis Guillemin, Andrew M. Demchuk, Bijoy K. Menon, Luís San Román, David S. Liebeskind, Phil White, Diederik W.J. Dippel, Antoni Dávalos, Serge Bracard, Peter Mitchell, Michael Wald, Stephen M. Davis, Kevin N. Sheth, W. Taylor Kimberly, Bruce Campbell, for the HERMES Collaborators
Abstract
In patients presenting with large hemispheric infarction, thrombectomy and reperfusion were not associated with MLS, except in the subgroup with very large core volume (>130 mL) in whom thrombectomy was associated with increased MLS due to space-occupying ischemic edema. Mitigating cerebral edema-mediated secondary injury in patients with very large infarcts may further improve outcomes after reperfusion therapies.
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