Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways
American Journal of Respiratory and Critical Care Medicine2018Vol. 199(6), pp. 715–727
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Kenichi Okuda, Gang Chen, Durai B. Subramani, M Wolf, Rodney C. Gilmore, Takafumi Kato, Giorgia Radicioni, Mehmet Kesımer, Michael Chua, Hong Dang, Alessandra Livraghi-Butrico, Camille Ehré, Claire M. Doerschuk, Scott H. Randell, Hirotoshi Matsui, Takahide Nagase, Wanda K. O’Neal, Richard C. Boucher
Abstract
In normal/healthy human airways, MUC5B is the dominant secretory mucin in the superficial epithelium and glands, with distal airways being a major site of expression. MUC5B and MUC5AC expression is a property of CCSP-positive secretory cells in superficial airway epithelia.
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