Role of Transforming Growth Factor–β in Airway Remodeling in Asthma

Citations Over TimeTop 1% of 2010 papers

Abstract

TGF-β is one of the main mediators involved in tissue remodeling in the asthmatic lung. This profibrotic cytokine is produced by a number of cells, including macrophages, epithelial cells, fibroblasts, and eosinophils. High expression of TGF-β in patients with asthma was reported by many investigators. However, controversy remains whether the concentration of TGF-β correlates with disease severity. TGF-β is believed to play an important role in most of the cellular biological processes leading to airway remodeling. It was shown to be involved in epithelial changes, subepithelial fibrosis, airway smooth muscle remodeling, and microvascular changes. Here, sources of TGF-β, as well as its role in the development of airway remodeling, will be reviewed. Therapeutic strategies that modulate TGF-β will also be discussed.

Related Papers

• → Cripto Binds Transforming Growth Factor β (TGF-β) and Inhibits TGF-β Signaling(2008)68 cited
• → Effect of Transforming Growth Factor-beta (TGF-β) on Mammary Development(2003)11 cited
• → Short-or long-term effects of a low-protein diet on fibronectin and transforming growth factor-β synthesis in Adriamycin-induced nephropathy(アドリアマイシン腎症における短期および長期の低蛋白食投与の効果 -フィブロネクチンおよびtransforming growth factor(TGF)-β産生について)(1997)
• The Progress in Researches on TGF-β and its Receptor in Marfan Syndrome(2008)
• → ELISA for quantification of transforming growth factor beta (TGF-β) in human serum or plasma. v1(2020)