Reduced Choroidal Neovascular Membrane Formation in Matrix Metalloproteinase-2–Deficient Mice
Investigative Ophthalmology & Visual Science2003Vol. 44(1), pp. 403–403
Citations Over TimeTop 12% of 2003 papers
Lennart Berglin, Sylvia Sarman, Ingeborg van der Ploeg, Bjo ̈rn Steen, Ming Yue, Shigeyoshi Itohara, Stefan Seregard, Anders Kvanta
Abstract
The present study demonstrated that MMP-2 mRNA and protein are upregulated during experimental CNV in the mouse. The marked difference in thickness of the CNV membrane between wild-type and MMP-2-deficient mice shows that MMP-2 is involved in the formation of experimental CNV in the mouse. These results suggest that pharmacologic targeting of MMPs, including MMP-2, may reduce formation of CNV in conditions such as age-related macular degeneration.
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