Pathogenic Role of Retinal Microglia in Experimental Uveoretinitis
Investigative Ophthalmology & Visual Science2003Vol. 44(1), pp. 22–22
Citations Over TimeTop 10% of 2003 papers
Narsing A. Rao, Takashi Kimoto, Ehud Zamir, Ranjit K. Giri, Robert Wang, Shinji Ito, Geeta Pararajasegaram, Russell W. Read, Guey‐Shuang Wu
Abstract
In the early phase of EAU, the microglia migrate to the photoreceptor cell layer where they generate TNFalpha and peroxynitrite. Such microglial migration and activation take place before infiltration of the macrophages. These findings indicate a novel pathogenic mechanism of EAU, in which retinal microglia may initiate retinitis with subsequent recruitment of circulation-derived phagocytes, leading to the amplification of uveoretinitis.
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