Insulin-like Growth Factor-I and its Receptor in Neovascular Age-Related Macular Degeneration
Investigative Ophthalmology & Visual Science2003Vol. 44(5), pp. 2192–2192
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Antoinette C. Lambooij, Karel H. M. van Wely, Dicky J. Lindenbergh-Kortleve, Robert W. A. M. Kuijpers, Mike Kliffen, Cornelia M. Mooy
Abstract
The colocalization of protein and receptor indicates an autocrine function of IGF-I in the normal human retina. Because IGF-I participates in ocular neovascularization, synthesis of IGF-IR and IGF-I in endothelial cells, RPE cells, and fibroblast-like cells in CNV may point toward a role for this growth factor in the pathogenesis of neovascular AMD.
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