Different Optineurin Mutation Pattern in Primary Open-Angle Glaucoma
Investigative Ophthalmology & Visual Science2003Vol. 44(9), pp. 3880–3880
Citations Over TimeTop 10% of 2003 papers
Yuk Fai Leung, Baojian Fan, Dennis S.C. Lam, Wing Shan Lee, Pancy O. S. Tam, John K.H. Chua, Clement C. Tham, Jimmy S.M. Lai, Dorothy S.P. Fan, Chi Pui Pang
Abstract
The findings in the current study enrich the evidence on the OPTN gene as a causative gene for POAG and suggest a different mutation pattern of OPTN in Chinese than in whites. The wide spectrum of putative mutations detected in this study suggests that both structural and functional disruptions in OPTN may contribute to the pathogenesis of glaucoma.
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