Periductal Area as the Primary Site for T-Cell Activation in Lacrimal Gland Chronic Graft-Versus-Host Disease
Investigative Ophthalmology & Visual Science2003Vol. 44(5), pp. 1888–1888
Citations Over TimeTop 10% of 2003 papers
Yoko Ogawa, Masataka Kuwana, Kazuto Yamazaki, Yukihiko Mashima, Masakazu Yamada, Takehiko Mori, Shinichiro Okamoto, Yoshihisa Oguchi, Yutaka Kawakami
Abstract
The results strongly suggest that CD4(+) and CD8(+) T cells in the lacrimal glands of patients with cGVHD are primarily activated in the periductal area through antigenic stimulation by potent antigen-presenting cells and stromal fibroblasts, and exert various effector functions, including cytotoxic effects on glandular epithelial cells.
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