Regulated Expression of Collagenases MMP-1, -8, and -13 and Stromelysins MMP-3, -10, and -11 by Human Corneal Epithelial Cells
Investigative Ophthalmology & Visual Science2003Vol. 44(7), pp. 2928–2928
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De Quan Li, Tie Yan Shang, Hyun Seung Kim, Abraham Solomon, Balakrishna L. Lokeshwar, Stephen C. Pflugfelder
Abstract
This study demonstrated that IL-1 beta and TNF-alpha upregulate collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, and -11) in human corneal epithelial cells. Doxycycline suppresses stimulated MMP-1, -13, and -10 at the mRNA and protein levels, which suggests that collagenases and stromelysins may play a role in the pathogenesis of sterile corneal ulceration and other ocular surface diseases.
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