Engraftment of Adult Neural Progenitor Cells Transplanted to Rat Retina Injured by Transient Ischemia
Investigative Ophthalmology & Visual Science2003Vol. 44(7), pp. 3194–3194
Citations Over TimeTop 17% of 2003 papers
Abstract
Adult hippocampus-derived neural progenitor cells transplanted to the subretinal space readily engraft into a host retina that has undergone ischemic injury. Many cells migrate to specific retinal cellular layers and undergo limited morphologic differentiation reminiscent of retinal neurons, including extension of processes into the optic nerve. Concurrent control studies demonstrate that optimal engraftment is achieved by subretinal delivery within a specific temporal window. These results imply that certain inductive cues may be regulated after injury, and they demonstrate the potential for adult neural progenitor cell transplantation for the treatment of retinal neurodegenerative diseases.
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