The Role of Advanced Glycation End Products in Retinal Microvascular Leukostasis
Investigative Ophthalmology & Visual Science2003Vol. 44(10), pp. 4457–4457
Citations Over TimeTop 10% of 2003 papers
Tara Moore, Jonathan E. Moore, Yuichi Kaji, Norma Frizzell, Tomohiko Usui, V. Poulaki, Iain L. Campbell, Alan W. Stitt, Tom A. Gardiner, D. B. Archer, Anthony P. Adamis
Abstract
AGEs caused upregulation of NFkappaB in the retinal microvascular endothelium and an AGE-specific increase in leukocyte adhesion in vitro was also observed. In addition, increased leukocyte adherence in vivo was demonstrated that was accompanied by blood-retinal barrier dysfunction. These findings add further evidence to the thinking that AGEs may play an important role in the pathogenesis of diabetic retinopathy.
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