Comparative Proteome Analysis of Native Differentiated and Cultured Dedifferentiated Human RPE Cells
Investigative Ophthalmology & Visual Science2003Vol. 44(8), pp. 3629–3629
Citations Over TimeTop 10% of 2003 papers
Claudia S. Alge, Sabine Suppmann, Siegfried Priglinger, Aljoscha S. Neubauer, Christian Albrecht May, Stefanie M. Hauck, Ulrich Welge‐Lüßen, Marius Ueffing, Anselm Kampik
Abstract
Dedifferentiation of human RPE cells in vitro results in downregulation of proteins associated with highly specialized functions of the RPE and induces the differential expression of proteins related to cytoskeleton organization, cell shape, cell migration, and mediation of proliferative signal transduction. These in vitro data suggest that the dedifferentiated status of RPE cells per se may initiate PVR. Further investigation of candidate proteins may identify additional targets for treatment or prevention of diseases associated with RPE dedifferentiation.
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