Cellular Retinaldehyde-Binding Protein Interacts with ERM-Binding Phosphoprotein 50 in Retinal Pigment Epithelium
Investigative Ophthalmology & Visual Science2004Vol. 45(2), pp. 393–393
Citations Over TimeTop 10% of 2004 papers
Maria Nawrot, Karen A. West, Jing Huang, Daniel E. Possin, Anthony Bretscher, John W. Crabb, John C. Saari
Abstract
RM proteins are multivalent linkers that connect plasma membrane proteins with the cortical actin cytoskeleton. EBP50 interacts with ERM family members through a C-terminal domain and binds targets such as CRALBP through its PDZ domains, thus contributing to an apical localization of target proteins. Our results provide a structural basis for apical localization of a retinoid-processing complex in RPE cells and offer insight into the cell biology of retinoid processing and trafficking in RPE.
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