A Retinal Neuronal Developmental Wave of Retinoschisin Expression Begins in Ganglion Cells during Layer Formation
Investigative Ophthalmology & Visual Science2004Vol. 45(9), pp. 3302–3302
Citations Over TimeTop 10% of 2004 papers
Yuichiro Takada, Robert N. Fariss, Atsuhiro Tanikawa, Yong Zeng, Deborah Carper, Ronald A. Bush, Paul A. Sieving
Abstract
All major classes of adult retinal neurons, with the possible exception of horizontal cells, express RS protein and mRNA, strongly suggesting that retinoschisin in the inner retina is synthesized locally rather than being transported, as earlier proposed, from distal retinal photoreceptors. Continued expression of RS by mature inner-retinal neurons supports the possibility of a therapeutic strategy of protein replacement to treat both infants and adults with XLRS.
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