Receptor for Advanced Glycation End Products and Age-Related Macular Degeneration
Investigative Ophthalmology & Visual Science2004Vol. 45(10), pp. 3713–3713
Citations Over TimeTop 10% of 2004 papers
Kimberly A. Howes, Yang Liu, Joshua L. Dunaief, Ann H. Milam, Jeanne M. Frederick, Alexander Marks, Wolfgang Baehr
Abstract
Immunolocalization of RAGE in RPE and photoreceptors coincided with AGE deposits and macular disease in aged, early AMD, and GA retinas. Further, AGE stimulated RAGE-mediated activation of cultured ARPE-19 cells in a dose-dependent fashion. AGE accumulation, as occurs with normal aging and in disease, may induce receptor-mediated activation of RPE/photoreceptor cells, contributing to disease progression in the aging human retinas.
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