Expression and Regulation of α-, β-, and γ-Crystallins in Mammalian Lens Epithelial Cells
Investigative Ophthalmology & Visual Science2004Vol. 45(10), pp. 3608–3608
Citations Over TimeTop 20% of 2004 papers
Abstract
BetaB1- and gammaS-crystallins are normally abundant in adult mammalian lens epithelial cells. Complex programs of transcription and degradation regulate the accumulation of crystallin mRNAs in lens epithelial cells after stress, at different ages, and during cell differentiation. Because crystallins selectively localize in distinct subcellular compartments during differentiation or stress, they may function to protect lens cells from injury. After stress, most alphaA- and alphaB-crystallin subunits are not in the same macromolecular complexes.
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