Classification of Fundus Autofluorescence Patterns in Early Age-Related Macular Disease
Investigative Ophthalmology & Visual Science2005Vol. 46(9), pp. 3309–3309
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Almut Bindewald-Wittich, Alan C. Bird, Samantha S. Dandekar, Joanna Dolar-Szczasny, Jens Dreyhaupt, F.W. Fitzke, W. Einbock, Frank G. Holz, Jork J. Jorzik, Claudia N. Keilhauer, Noemi Lois, Juliane Mlynski, Daniel Pauleikhoff, Giovanni Staurenghi, Sebastián Wolf
Abstract
Various phenotypic patterns of abnormal FAF can be identified with cSLO imaging. Distinct patterns may reflect heterogeneity at a cellular and molecular level in contrast to a nonspecific aging process. The results indicate that the classification system yields a relatively high degree of intra- and interobserver agreement. It may be applicable for determination of novel prognostic determinants in longitudinal natural history studies, for identification of genetic risk factors, and for monitoring of future therapeutic interventions to slow the progression of early AMD.
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