Photopic ERGs in Patients with Optic Neuropathies: Comparison with Primate ERGs after Pharmacologic Blockade of Inner Retina
Investigative Ophthalmology & Visual Science2004Vol. 45(10), pp. 3827–3827
Citations Over TimeTop 10% of 2004 papers
Nalini Rangaswamy, Laura J. Frishman, E. Ulysses Dorotheo, Jade S. Schiffman, Hasan M. Bahrani, Rosa A. Tang
Abstract
PhNR amplitude is significantly reduced in eyes with open-angle glaucoma, AION, and compressive optic neuropathy. Experiments in primates indicate that this reduction reflects loss of a spike-driven contribution to the photopic ERG. There also are small spike-driven contributions to the a-wave elicited by full-field red stimuli. The i-wave, which becomes more prominent when the PhNR is reduced, has origins in the off-pathway distal to the ganglion cells.
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