Paired-Flash Identification of Rod and Cone Dysfunction in the Diabetic Rat
Investigative Ophthalmology & Visual Science2004Vol. 45(12), pp. 4592–4592
Citations Over TimeTop 16% of 2004 papers
Abstract
Retinal neural dysfunction was observed as early as 2 days after STZ injection. These acute changes reflect either STZ toxicity or hyperglycemia as a result of pancreatic compromise. Consistent loss over the 12 weeks of the cone response and OPs suggests a vulnerability of the inner retina to STZ-related effects. The 12-week losses in function of retinal neurons are consistent with a generalized diabetic neuropathy, since impaired function developed simultaneously in both inner and outer retinal neurons.
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