Vascular Damage in a Mouse Model of Diabetic Retinopathy: Relation to Neuronal and Glial Changes
Investigative Ophthalmology & Visual Science2005Vol. 46(11), pp. 4281–4281
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Rachel A. Feit-Leichman, Reiko Kinouchi, Masumi Takeda, Zhigang Fan, Susanne Mohr, Timothy S. Kern, Dong Feng Chen
Abstract
Diabetic C57Bl/6J mice develop capillary lesion that are characteristic of the early stages of diabetic retinopathy in patients. The data suggest that diabetes-induced degeneration of retinal capillaries can develop independent of neuronal loss or chronic GFAP upregulation in glial cells.
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