Three NovelPax6Alleles in the Mouse Leading to the Same Small-Eye Phenotype Caused by Different Consequences at Target Promoters
Investigative Ophthalmology & Visual Science2005Vol. 46(12), pp. 4671–4671
Citations Over TimeTop 11% of 2005 papers
Jochen Graw, Jana Lo ̈ster, Oliver Puk, Doris Mu ̈nster, Nicole Haubst, Dian Soewarto, Helmut Fuchs, Birgit Meyer, Peter Nu ̈rnberg, Walter Pretsch, Paul B. Selby, Jack Favor, Eckhard Wolf, Martin Hrabě de Angelis
Abstract
Together with functional analysis in a reporter gene assay and immunohistochemistry using Pax6 antibodies, it is suggested that the Pax6Aey11 and Pax6Aey18 alleles act through a loss of function, whereas ADD4802 represents a gain-of-function allele.
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