Proteinase and Growth Factor Alterations Revealed by Gene Microarray Analysis of Human Diabetic Corneas
Investigative Ophthalmology & Visual Science2005Vol. 46(10), pp. 3604–3604
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Mehrnoosh Saghizadeh, Andrei A. Kramerov, Jian Tajbakhsh, Annette M. Aoki, Charles Wang, Ning-ning Chai, Julia Y. Ljubimova, Takako Sasaki, Gabriel Sosne, Marc Carlson, Stanley F. Nelson, Alexander V. Ljubimov
Abstract
Elevated cathepsin F and the ability of its inhibitor to produce a more normal phenotype in diabetic corneas suggest increased proteolysis in these corneas. Proteinase changes may result from abnormalities of growth factors, such as HGF and FGF-3, in DR corneas. Specific modulation of proteinases and growth factors could reduce diabetic corneal epitheliopathy.
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