Multiphoton Autofluorescence and Second-Harmonic Generation Imaging of the Ex Vivo Porcine Eye
Investigative Ophthalmology & Visual Science2006Vol. 47(3), pp. 1216–1216
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Shu‐Wen Teng, Hsin‐Yuan Tan, Ju-Li Peng, Huei-Hsing Lin, Ki Hean Kim, Wen Lo, Yen Sun, Wei‐Chou Lin, Sung‐Jan Lin, Shiou‐Hwa Jee, Peter T. C. So, Chen‐Yuan Dong
Abstract
Multiphoton autofluorescence and SHG microscopy have been demonstrated to be an effective technique for resolving, respectively, the cellular and collagen structures within the ocular surface of ex vivo porcine eyes. SHG imaging resolved the difference in structural orientations between corneal and sclera collagen fibers. Specifically, the corneal collagen is organized in a depth-dependent fashion, whereas the scleral collagen is randomly packed. Because this technique does not require histologic preparation procedures, it has the potential to be applied for in vivo studies with minimal disturbance to the eye.
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