Late-Onset Macular Degeneration and Long Anterior Lens Zonules Result from aCTRP5Gene Mutation
Investigative Ophthalmology & Visual Science2005Vol. 46(9), pp. 3363–3363
Citations Over TimeTop 10% of 2005 papers
Radha Ayyagari, Md Nawajes A. Mandal, Athanasios J. Karoukis, Lianchun Chen, Ning C. McLaren, Mona Lichter, David T. Wong, Peter F. Hitchcock, Rafael C. Caruso, Sayoko E. Moroi, Irene H. Maumenee, Paul A. Sieving
Abstract
A single locus at 11q23 is implicated in a complex ocular phenotype involving RPE and CE, tissues of neuroectodermal origin. All individuals with either LAZ and/or macular degeneration carry the same CTRP5 S163R mutation, which is transmitted in autosomal dominant manner.
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