Role of the Norrie Disease Pseudoglioma Gene in Sprouting Angiogenesis during Development of the Retinal Vasculature
Investigative Ophthalmology & Visual Science2005Vol. 46(9), pp. 3372–3372
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Ulrich F. O. Luhmann, Jihong Lin, Niyazi Acar, Stefanie Lammel, Silke Feil, Christian Grimm, Mathias W. Seeliger, Hans‐Peter Hammes, Wolfgang Berger
Abstract
These data provide evidence for a crucial role of Norrin in hyaloid vessel regression and in sprouting angiogenesis during retinal vascular development, especially in the development of the deep retinal capillary networks. They also suggest an early and a late phase of Norrie disease and may provide an explanation for similar phenotypic features of allelic retinal diseases in mice and patients as secondary consequences of pathologic hypoxia.
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