Differential Gene Expression in Pseudoexfoliation Syndrome
Investigative Ophthalmology & Visual Science2005Vol. 46(10), pp. 3742–3742
Citations Over TimeTop 10% of 2005 papers
Matthias Zenkel, Ernst Po ̈schl, Klaus von der Mark, Carmen Hofmann-Rummelt, Gottfried O.H. Naumann, Friedrich E. Kruse, Ursula Schlo ̈tzer-Schrehardt
Abstract
Differentially expressed genes with a high level of reproducibility in different tissues and different patients with PEX syndrome are mainly related to extracellular matrix metabolism and cellular stress. The underlying pathophysiology of PEX syndrome appears to be associated with an excessive production of elastic microfibril components, enzymatic cross-linking processes, a proteolytic imbalance between matrix metalloproteinases and their inhibitors, and increased cellular and oxidative stress supporting the notion of PEX syndrome as a stress-induced elastic microfibrillopathy.
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