Botulinum Toxin B-Induced Mouse Model of Keratoconjunctivitis Sicca
Investigative Ophthalmology & Visual Science2005Vol. 47(1), pp. 133–133
Citations Over TimeTop 13% of 2005 papers
Olan Suwan‐apichon, Michael Rizen, Ram Rangsin, Samantha Herretes, Johann M.G. Reyes, Kaevalin Lekhanont, Roy S. Chuck
Abstract
Intralacrimal gland injection of BTX-B resulted in persistent corneal fluorescein staining within 3 days, and a significant decrease in aqueous tear production that persisted for 1 month. Intralacrimal gland injection of BTX-B suppressed lacrimation, thereby establishing a dry eye state. This animal model could be a useful tool for investigating the pathogenesis of the chronic condition KCS in humans.
Related Papers
- → Is the lacrimal gland dispensable? Keratoconjunctivitis sicca after lacrimal gland removal(1975)10 cited
- → Ocular surface Rose Bengal staining in normal dogs and dogs with Keratoconjunctivitis Sicca: Preliminary findings(2017)6 cited
- → Ocular surface Rose Bengal staining in normal dogs and dogs with Keratoconjunctivitis Sicca: Preliminary findings(2017)6 cited
- → Factors Affecting Triple Staining of Human Sperm(1981)14 cited
- Ocular surface staining characteristics of lissamine green and rose bengal in patients with Keratoconjunctivitis Sicca and Primary Sjogren's Syndrome(1997)