Reductions in Serum Vitamin A Arrest Accumulation of Toxic Retinal Fluorophores: A Potential Therapy for Treatment of Lipofuscin-Based Retinal Diseases
Investigative Ophthalmology & Visual Science2005Vol. 46(12), pp. 4393–4393
Citations Over TimeTop 10% of 2005 papers
Roxana A. Radu, Yun Han, T. V. Bui, Steven Nusinowitz, Dean Bok, Jay B. Lichter, Ken Widder, Gabriel H. Travis, Nathan L. Mata
Abstract
These findings demonstrate the vitamin A-dependent nature of A2E biosynthesis and validate a novel therapeutic approach with potential to halt the accumulation of lipofuscin fluorophores in the eye.
Related Papers
- → Rpe65 as a modifier gene for inherited retinal degeneration(2006)74 cited
- → Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration.(1995)130 cited
- → Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D–generated signaling lipid(2005)57 cited
- → Do cGMP Levels Drive the Speed of Photoreceptor Degeneration?(2018)8 cited
- → Mutation of a TADR Protein Leads to Rhodopsin and Gq-Dependent Retinal Degeneration inDrosophila(2008)8 cited